Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the finish associated with century that is 19th cannabis ended up being a mainstream treatment for preventing and relieving migraines as well as other forms of headaches. Numerous doctors advocated for the use until the 1940s, whenever cannabis had been taken out of the formal pharmacopeias due to its “high possibility of abuse” 1+, 2.

The current legalization of medical marijuana and CBD oil in many nations worldwide revived the almost-forgotten utilization of cannabis for headaches. Nonetheless, it is crucial to see that the actual only real use that is medical of authorized because of the FDA would be to reduce seizures in 2 forms of epilepsy 3.

Migraines along with other forms of headaches are, after joint disease, the conditions that are painful commonly improved with CBD oil. In a survey on 1500 medical CBD users, around one away from six reported struggling with headaches 4.

30% of medical cannabis users reported doing this to alleviate migraines as well as other headaches in 2 studies on nearly 2500 individuals. Nevertheless, the essential variety that is popular them had been “OG Shark,” a THC-rich hybrid strain with a low CBD content 5, 6.

This departs us with all the relevant question: does CBD oil alone relieve migraines as well as other kinds of headaches or must you take THC-containing cannabis strains to obtain the pain-relieving benefits? Let’s look in the technology of CBD first to obtain the responses.

How Exactly Does It Work?

Regardless of type, headaches include an overactivation of nerves attached to arteries when you look at the mind (trigeminovascular system) 2, 7+.

Released vessel-widening proteins (CGRP and substance P) and messengers (NO) enhance blood circulation, which stimulates discomfort receptors on neurological cells when you look at the mind and throat. Headaches are a definite result that is direct of stimulation, while medications for headaches frequently block these receptors 2, 7+.

Boosts cannabinoids that are natural

The system that is endocannabinoid consists of two receptors: CB1 and CB2. Both THC from cannabis while the cannabinoids obviously generated by the human body, such as for example anandamide, relieve pain by activating these receptors 8, 10, 11.

CBD is significantly diffent: it blocks as opposed to activates these receptors. But, it prevents anandamide from being separated. Interestingly, a concept through the very early 21st century linked migraines (along with other chronic discomfort conditions) with low anandamide levels 12, 10, 13, 14, 15.

In fact, further studies revealed that folks – and specially ladies – with migraines usually have less anandamide within the spinal fluid and platelets 16, 17, 18.

Exactly the same ended up being real in people who have headaches from overusing painkillers; after they withdrew through the medications, that they had less breakdown that is anandamide pain 19, 20.

Individuals with chronic headaches have actually reduced anandamide levels and greater CGRP and NO production. CB1 activation by anandamide and cannabinoids that are synthetic the manufacturing of CGRP with no, which prevents (trigeminovascular) neurological overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers associated with the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor includes a role that is well-known relieving headaches and its own activators (called triptans) are mainstream drugs for migraines 25, 26, 27.

CBD may reduce neurological discomfort by activating another serotonin receptor (5HT1A), which will be based in the back in place of when you look at the mind 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor associated with inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases the flow of blood towards the nerves that are trigeminal. This shows that CBD might cause headaches 14, 32, 33, 34, 35.

Nevertheless, repeated TRPV1 activation reduces sensitiveness to discomfort. Certainly, a nose spray with all the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a tiny trial on 8 individuals 14, 36+.

Obstructs Glutamate

Alterations in eyesight, flexibility, or message called aura typically precede migraine assaults. These harbingers that are migraine due to glutamate overactivation when you look at the mind. Anandamide, THC, and cannabinoids that are synthetic glutamate receptors, suggesting they assist in preventing auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune conditions may trigger migraines as well as other forms of headaches when they result swelling for the bloodstream when you look at the mind. Certainly, conditions such as for example numerous sclerosis, lupus, Sjцgren problem, and antiphospholipid problem are related to regular headaches 41.

CBD may relieve headaches in individuals with these conditions through its strong activity that is anti-inflammatory. It decreases the production of pro-inflammatory messengers (such as for instance IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while increasing the quantities of the anti inflammatory cytokines IL-4 and IL-10 43, 44, 45, 46, 47.

Instead, it could avoid the the signs of autoimmune disorders by curbing the resistant reaction. As an example, CBD prevented T cells from building and multiplying up into the minds of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 response 48, 49.

Whenever Does It Work?


In a report on over 100 individuals with migraines utilizing medicinal cannabis (with both CBD and THC), 85% reported paid down pain and frequency 50 that is migraine.

A preparation with more CBD than THC prevented attacks as effectively as a migraine drug (amitriptyline) in a clinical trial on 79 people with chronic migraines. a dose that is additional the assaults reduced pain. Likewise, 3 cannabis that are heavy began having migraines once they stopped; one got rest from smoking once again 51.

THC may account fully for a part that is great of impacts. THC alone prevented migraine assaults and paid off pain in rats. In comparison, its overuse could have the contrary impact: high doses increased sensitivity to duplicated nerve stimulation – a suspected migraine trigger 53, 54.

Taken together, there isn’t any proof that CBD oil improves migraines. Studies in rats also claim that THC in the place of CBD could be the cannabinoid responsible for the pain sensation relief seen in individuals cannabis that are using for migraines.

Other styles of Headaches

In a scholarly research on over 100 individuals with cluster headaches, 45% utilized cannabis but only 25% skilled relief while 22percent felt even worse 55.

In a single report, recreational marijuana and synthetic THC (dronabinol) enhanced frequent cluster headaches in a teen. The power had been likely from THC, not CBD 56.

In an endeavor on 13 individuals with headaches from overusing painkillers, cannabis preparations pain that is reduced. But, the planning with all the THC content that is highest (oil) was far better. In accordance with this, a artificial compound that is THCnabilone) reduced discomfort as well as the dependence on painkillers a lot better than ibuprofen in another test on 26 individuals 57, 58.

Within the term that is short THC as well as other CB1 activators additionally relieved headaches from painkillers in rats. Nevertheless, their duplicated use increased sensitiveness to discomfort meaning that is might trigger migraines 54.

Both medical cannabis and an artificial THC element (dronabinol) relieved headaches in 2 ladies with a high stress into the brain (pseudotumor cerebri) 59+, 60.

A couple of clinical and animal studies recommend that CBD is perhaps inadequate for group headaches and headaches from overusing painkillers. THC is apparently the only cannabinoid providing some pain alleviation, however the proof remains limited.


There are not any clinical studies testing CBD alone for headaches. Many of them used cannabis preparations with adjustable quantities of THC and CBD.

Many people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been additionally effective. This implies that migraine relief requires direct activation that is CB1 only THC is likely to attain. Having said that, CBD may help by boosting slightly anandamide levels.

CBD Oil Dosage for Migraines


Because CBD isn’t approved for migraines or other forms of headaches, there is absolutely no dose that is official. There is certainly no confirmed dosage either because CBD alone hasn’t been tested in medical studies. The study that is only a product higher in CBD than in THC (9% vs 0.4%) utilized a dose of 200 mg (supplying 18 mg CBD) a day. Nevertheless, we can’t rule the contribution out of its THC content to your results 51+.

We could also calculate dosage in line with the directions from manufacturers and users.

One maker of a commercial oil specifically formulated for migraines recommends 1 mL (providing 33 mg CBD) per day.

Natural wellness blog sites and users choose reduced doses (15-25 mg/day). They often suggest beginning with a dose that is low increasing it until noticing pain-relieving results. It’s crucial to get this done slowly, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or just about any therapies that are unproven migraines and headaches without consulting your medical professional upfront. Check with your physician if CBD oil can help for you personally and just what dose and form that is delivery be much better for your needs.

How exactly to make use of

CBD oil comes in different kinds. Your type of option might rely on your form of frustration 62+:

  • Vaping, lips sprays, and oil tinctures are consumed quickly and offer pain relief that is temporary. They may are more effective for cyclically-arising headaches such as for instance cluster headaches.
  • Capsules, edibles, and teas release the CBD more gradually however their effects last for a longer time. They might be better for conditions with constant discomfort such as headaches from overusing painkillers.

Although migraine discomfort just isn’t constant, slow-release CBD kinds might be more efficient (according to CBD’s relationship with all the TRPV1 receptor). Acute CBD doses may trigger attacks that are migraine duplicated doses decrease pain perception.

Anecdotal proof from internet forums recommends using cannabis that are medicinal soon after just starting to sense the onset of a migraine or cluster hassle attack 61.

Most readily useful CBD Oil for Migraines

As well as selecting a CBD oil modified to your allowance (you might want to determine the price per mL or mg to compare various brands), its also wise to measure the product quality. Read here on how to select the CBD oil that is best.


The viewpoints expressed in this part are solely those of CBD oil users whom may or might not have medical or training that is scientific. Their reviews usually do not represent the viewpoints of SelfHacked. SelfHacked will not endorse any product that is specific solution, or therapy.

Usually do not consider user experiences as medical advice. Never ever wait or disregard looking for professional advice that is medical your physician or any other qualified medical providers as a result of something you have got keep reading SelfHacked. We cbd oil realize that reading specific, real-life experiences may be a helpful resource, but it is never ever an alternative for health-related advice, diagnosis, or treatment from a qualified doctor.

The most common frustration type among CBD oil users had been migraine, followed closely by tension headache, and frustration from painkiller overuse or conditions such as for instance fibromyalgia. A lot of them had been satisfied and reported good pain relief. The users reported some added benefits such as improving sleep quality and curbing anxiety in several cases.

Some users reported that the oil didn’t work for them or so it made them drowsy and fatigued. CBD oil even caused headaches in certain social individuals using it at high doses.


Most people with migraines utilize THC-rich cannabis strains, while some prefer CBD oil. No medical research reports have yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may alleviate headaches – but just within the long haul and not likely along with THC.

Sudden surges in CBD, such as for example from vaping, could cause migraines. But taken long-lasting, CBD may decrease pain perception and stop auras that are migraine. It primarily functions by boosting your normal cannabinoid bliss particles.

CBD oil can also be a choice for those who have migraines and headaches from autoimmune diseases like lupus and multiple sclerosis. In such instances, it probably helps by decreasing mind suppressing and inflammation autoimmunity.

Opt for capsules or edibles and take them every time for top level outcomes.

Vendors offer CBD oil on Amazon, however, many of those usually do not meet quality criteria. Some don’t even specify the CBD content inside their items, while other people offer hemp oil with small or no CBD. Many of these vendors are not to ever be trusted.

We suggest the following brand name, which specifies quality procedures and CBD content inside their services and products:

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